貨號	規格	價格	上海	北京	武漢	南京
S80530-2mg	≥99%(HPLC)	￥200.00 S80530-2mg ￥200.00 現貨	3 3	-	-	-
S80530-5mg	≥99%(HPLC)	￥280.00 S80530-5mg ￥280.00 現貨	6 6	-	-	-
S80530-10mg	≥99%(HPLC)	￥550.00 S80530-10mg ￥550.00 現貨	13 >10	-	-	-
S80530-25mg	≥99%(HPLC)	￥890.00 S80530-25mg ￥890.00 現貨	9 9	-	-	-
S80530-50mg	≥99%(HPLC)	￥1600.00 S80530-50mg ￥1600.00 現貨	8 8	-	-	-
S80530-100mg	≥99%(HPLC)	￥3000.00 S80530-100mg ￥3000.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Micafungin Sodium is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.

產品描述：

Micafungin Sodium is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.

靶點：

Antibiotic;Antifungal

體外研究：

Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone.

體內研究：

Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals.

細胞實驗：

Each fungal isolate is incubated statically in yeast-maltose (YM) agar broth for 24?h at 30°C. Cryptococcus neoformans YC203 is grown in YM broth medium for 20?h at 30°C with shaking at 200?r.p.m. A cell suspension is prepared by washing the cultured cells once with sterile saline. A. fumigatus FP1305 is cultured on a potato dextrose agar (PDA) slant for 4 days, and spores are then harvested in sterile saline and collected by filtering through gauze. Antifungal activity against all isolates, with the exception of C. neoformans, is measured by the micro-broth dilution method in 96-well culture plates using RPMI 1640 medium supplemented with l-glutamine, but without sodium bicarbonate, and buffered to pH 7.0 with 0.165?m MOPS. ForC. neoformans, yeast nitrogen base-glucose (YNBD) medium is used. For the assay, the test microorganism is inoculated into each well to yield 1×105?CFU/well, and the plates are then incubated for 20?h or 48?h at 37°C. Two end points are determined by microscopic observation: MEC, which

參考文獻：

1. Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing[J]. Mycoses. 2020, 63(12): 1283-1298. 2. Kai H, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigat us and its efficacy in murine infection models. J Antibiot (Tokyo). 2013 Jun 12. 3. Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23. 4. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing[J]. Emerging microbes & infections. 2019;8(1):531-541.

溶解性：

Soluble in DMSO、H2O

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	0.774 ml	3.869 ml	7.738 ml
5 mM	0.155 ml	0.774 ml	1.548 ml
10 mM	0.077 ml	0.387 ml	0.774 ml
50 mM	0.015 ml	0.077 ml	0.155 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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Micafungin Sodium

sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pe