貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京	購(gòu)買數(shù)量
S80524-10mg	98.0%	￥415.00 S80524-10mg ￥415.00 現(xiàn)貨	5 5	-	-	-
S80524-50mg	98.0%	￥1650.00 S80524-50mg ￥1650.00 現(xiàn)貨	10 10	-	-	-

產(chǎn)品介紹

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action

產(chǎn)品描述：

靶點(diǎn)：

MDM-2/p53HIF/HIF;Prolyl-Hydroxylase;HIF/HIFProlyl-Hydroxylase

體內(nèi)研究：

Amifostine (i.v., 400 mg/kg, 4 h) has a protective effect against myocardial I/R injury in male C57BL/6 mice

參考文獻(xiàn)：

1. Kouvaris, J.R., V.E. Kouloulias, and L.J. Vlahos, Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist, 2007. 12(6): p. 738-47. 2. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40. 3. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37. 4. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14. 5. Shao-Ze Wu, et al. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2017;2017:4130824.

溶解性：

H2O : 100 mg/mL (466.81 mM; Need ultrasonic) DMF : 1 mg/mL (4.67 mM; Need ultrasonic) DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.668 ml	23.34 ml	46.681 ml
5 mM	0.934 ml	4.668 ml	9.336 ml
10 mM	0.467 ml	2.334 ml	4.668 ml
50 mM	0.093 ml	0.467 ml	0.934 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(2篇)

2. [IF=4.142] Zhang Hao et al."A portable personal glucose meter method for enzyme activity detection and inhibitory activity evaluation based on alkaline phosphatase-mediated reaction."Anal Bioanal Chem. 2021 Apr;413(9):2457-2466 1. [IF=10.317] Jiani Xie et al."Graphdiyne nanoradioprotector with efficient free radical scavenging ability for mitigating radiation-induced gastrointestinal tract damage."Biomaterials. 2020 Jun;244:119940

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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