貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80519-1mg	99.9%	￥60.00 S80519-1mg ￥60.00 現(xiàn)貨	19 >10	-	-	-
S80519-5mg	≥99%	￥80.00 S80519-5mg ￥80.00 2-3天	0 貨期：2-3天	-	-	-
S80519-10mg	99.9%	￥130.00 S80519-10mg ￥130.00 現(xiàn)貨	12 >10	-	-	-
S80519-25mg	≥99%	￥270.00 S80519-25mg ￥270.00 2-3天	0 貨期：2-3天	-	-	-
S80519-50mg	99.9%	￥480.00 S80519-50mg ￥480.00 現(xiàn)貨	7 7	-	-	-
S80519-100mg	≥99%	￥920.00 S80519-100mg ￥920.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity

產(chǎn)品描述：

靶點(diǎn)：

IC50: < 25 nM (NAMPT);Apoptosis;NAMPT

體內(nèi)研究：

A 4-h iv infusion of NA (120 mg/kg of body weight) did not adversely affect the antitumor activity of a 24-h iv infusion of CHS-828 (GMX1778) at a dose of 150 mg/kg or 650 mg/kg in the NAPRT1-deficient xenograft experiments. CHS-828 (GMX1778) at 650 mg/kg is above the maximum tolerated dose. The administration of NA as a 4-h iv infusion immediately following treatment with 750 mg/kg CHS-828 (GMX1778) reduced the mortality associated with toxic doses of GMX1777

參考文獻(xiàn)：

1. Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29(21):5872-88. 2. Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner

溶解性：

DMSO : ≥ 39 mg/mL (104.88 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.689 ml	13.446 ml	26.891 ml
5 mM	0.538 ml	2.689 ml	5.378 ml
10 mM	0.269 ml	1.345 ml	2.689 ml
50 mM	0.054 ml	0.269 ml	0.538 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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