貨號	規格	價格	上海	北京	武漢	南京
S80504-10mg	99.2%	￥40.00 S80504-10mg ￥40.00 現貨	3 3	-	-	-
S80504-50mg	99.2%	￥120.00 S80504-50mg ￥120.00 現貨	7 7	-	-	-
S80504-100mg	99.2%	￥200.00 S80504-100mg ￥200.00 現貨	6 6	-	-	-
S80504-250mg	99.2%	￥320.00 S80504-250mg ￥320.00 現貨	2 2	-	-	-

產品介紹

Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivit. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM

產品描述：

靶點：

HIV;HIV Protease;SARS-CoV;SARS-CoV;HIVProtease

體內研究：

Coadministration with low-dose Ritonavir significantly improves the pharmacokinetic properties and hence the activity of Lopinavir against HIV-1 protease

參考文獻：

1. Cvetkovic RS, et al. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs. 2003;63(8):769-802. 2. Sham HL, et al. ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob Agents Chemother. 1998;42(12):3218-3224. 3. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.

溶解性：

DMSO : 250 mg/mL (397.58 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.59 ml	7.952 ml	15.903 ml
5 mM	0.318 ml	1.59 ml	3.181 ml
10 mM	0.159 ml	0.795 ml	1.59 ml
50 mM	0.032 ml	0.159 ml	0.318 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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