貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80481-10mg	99.8%	￥80.00 S80481-10mg ￥80.00 現(xiàn)貨	12 >10	-	-	-
S80481-50mg	99.8%	￥260.00 S80481-50mg ￥260.00 現(xiàn)貨	3 3	-	-	-
S80481-100mg	≥99%	￥450.00 S80481-100mg ￥450.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine. IC50: Target: 5-hydroxytryptamine1B/1D (5-HT1B/1D) Receptor Almotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults. Almotriptan showed low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors in several species, including the human, while affinity for 5-HT receptors other than 5-HT(1B/1D) was clearly less. Almotriptan did not exhibit significant affinity for several non-5-HT receptors studied up to 100 microM. Almotriptan inhibited forskolin-stimulated cyclic AMP accumulation in HeLa cells transfected with 5-HT(1B) or 5-HT(1D) human receptors. Almotriptan had a mild antiemetic effect and a slight, transient diuretic effect in dogs, although the latter effect is probably of no clinical relevance. In addition, no effect on the respiratory system of conscious guinea pigs was observed following almotriptan treatment. These results indicate that almotriptan has a favourable safety profile with respect to the central nervous, renal and respiratory systems

產(chǎn)品描述：

靶點(diǎn)：

5-HT1B Receptor;5-HT1D Receptor;5-HTReceptor

參考文獻(xiàn)：

1. Bou J , et al. Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur J Pharmacol, 2000. 410(1): p. 33-41. 2. Gras J, et al. Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics. Arzneimittelforschung, 2001. 51(9): p. 726-32.

溶解性：

DMSO : 100 mg/mL (212.97 mM; Need ultrasonic) H2O : 33.33 mg/mL (70.98 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.13 ml	10.648 ml	21.297 ml
5 mM	0.426 ml	2.13 ml	4.259 ml
10 mM	0.213 ml	1.065 ml	2.13 ml
50 mM	0.043 ml	0.213 ml	0.426 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(shū)(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(shū)(COA)?

請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
在貨品標(biāo)簽上如何找到貨號(hào)和批號(hào)?

摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計(jì)算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费