貨號	規格	價格	上海	北京	武漢	南京
S80459-2mg	98.2%	￥300.00 S80459-2mg ￥300.00 現貨	6 6	-	-	-
S80459-5mg	98.2%	￥600.00 S80459-5mg ￥600.00 現貨	3 3	-	-	-
S80459-10mg	98.2%	￥960.00 S80459-10mg ￥960.00 現貨	8 8	-	-	-
S80459-25mg	98.2%	￥2000.00 S80459-25mg ￥2000.00 現貨	5 5	-	-	-
S80459-50mg	98.2%	￥3800.00 S80459-50mg ￥3800.00 現貨	2 2	-	-	-
S80459-100mg	≥98%	￥6000.00 S80459-100mg ￥6000.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively

產品描述：

靶點：

sPLA2:9 nM (IC50);Phospholipase

體內研究：

Varespladib treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib is 16.1 mg/kg

參考文獻：

1. Snyder DW, et al. Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1 2. Hori Y, et al. Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.

溶解性：

DMSO : 100 mg/mL (262.89 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.629 ml	13.144 ml	26.289 ml
5 mM	0.526 ml	2.629 ml	5.258 ml
10 mM	0.263 ml	1.314 ml	2.629 ml
50 mM	0.053 ml	0.263 ml	0.526 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(2篇)

2. [IF=7.4] Jiahao Liu et al."Varespladib attenuates Naja atra-induced acute liver injury via reversing Nrf2 signaling-mediated ferroptosis and mitochondrial dysfunction."REDOX REPORT. 1. [IF=2.8] Wenjie Zhao et al."Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA2."TOXICON".2024 Mar;:107694

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