品牌	貨號	產品規格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S80420-1mg	98%	￥250.00元	10	-	-	-
源葉(MedMol)	S80420-5mg	98%	￥425.00元	6	-	-	-
源葉(MedMol)	S80420-10mg	98%	￥595.00元	6	-	-	-
源葉(MedMol)	S80420-25mg	98%	￥1280.00元	預計交期：2-3天	-	-	-
源葉(MedMol)	S80420-50mg	98%	￥2250.00元	預計交期：2-3天	-	-	-
源葉(MedMol)	S80420-100mg	98%	￥3200.00元	預計交期：2-3天	-	-	-

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產品介紹

TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research

產品描述： TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research

靶點： IC50: 0.8 nM (MTH1);DNA/RNASynthesis;MTH1

體外研究：
TH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells

體內研究：
TH287 (5 mg/kg; i.p.) exhibits Cmax of 0.82 μM and tmax of 0.5 h in mice

參考文獻：
1. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21. 2. Saleh A, et, al. Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma. J Pharm Biomed Anal. 2015 Feb;104:1-11.

溶解性： soluble in DMSO

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.716 ml	18.578 ml	37.157 ml
5 mM	0.743 ml	3.716 ml	7.431 ml
10 mM	0.372 ml	1.858 ml	3.716 ml
50 mM	0.074 ml	0.372 ml	0.743 ml

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部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

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