貨號	規(guī)格	價格	上海	北京	武漢	南京
S80406-1mg	≥98%	￥110.00 S80406-1mg ￥110.00 2-3天	0 貨期：2-3天	-	-	-
S80406-5mg	99.3%	￥315.00 S80406-5mg ￥315.00 現(xiàn)貨	3 3	-	-	-
S80406-10mg	99.3%	￥600.00 S80406-10mg ￥600.00 現(xiàn)貨	6 6	-	-	-
S80406-25mg	≥98%	￥1450.00 S80406-25mg ￥1450.00 2-3天	0 貨期：2-3天	-	-	-
S80406-50mg	99.3%	￥2800.00 S80406-50mg ￥2800.00 現(xiàn)貨	2 2	-	-	-

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產(chǎn)品介紹

SGC0946 is a selective DOT1LH3K79 methyltransferase) inhibitor, with an IC50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells

產(chǎn)品描述：

靶點(diǎn)：

DOT1L:0.3 nM (IC50);HistoneMethyltransferase

體內(nèi)研究：

SGC0946 (10 mg/kg; i.p.; twice a week for 6 weeks) significantly suppresses tumor progression in a mouse orthotopic xenograft ovarian cancer model and also inhibits DOT1L enzymatic activity and levels of H3K79me2,CDK6, and cyclin D3 in the tumors

參考文獻(xiàn)：

1. Yu W, et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun. 2012;3:1288. 2. Zhang X, et al. Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer. J Hematol Oncol. 2017 Jan 23;10(1):29. 3. Zhang L, et al. Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. Oncotarget. 2014 Nov 15;5(21):10665-77.

溶解性：

DMSO : 50 mg/mL (80.83 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.617 ml	8.083 ml	16.166 ml
5 mM	0.323 ml	1.617 ml	3.233 ml
10 mM	0.162 ml	0.808 ml	1.617 ml
50 mM	0.032 ml	0.162 ml	0.323 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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SGC-0946