貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80402-5mg	≥99%(HPLC)	￥280.00 S80402-5mg ￥280.00 現(xiàn)貨	3 3	-	-	-
S80402-10mg	≥99%(HPLC)	￥480.00 S80402-10mg ￥480.00 現(xiàn)貨	7 7	-	-	-
S80402-50mg	≥99%(HPLC)	￥1120.00 S80402-50mg ￥1120.00 2-3天	0 貨期：2-3天	-	-	-
S80402-250mg	≥99%(HPLC)	￥3600.00 S80402-250mg ￥3600.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Trapidil is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease.

產(chǎn)品描述：

靶點(diǎn)：

PDGFR;PDE

體內(nèi)研究：

Trapidil is an antiplatelet drug with specific platelet-derived growth factor antagonism and antiproliferative effects in the rat and rabbit models after balloon angioplasty. Trapidil had a potent inhibitory effect on osteoclast formation and bone resorption induced by interleukin-1 in an animal model. No abnormal symptoms, such as changes in body weight, diarrhea, high fever, and convulsion, were observed after intraperitoneal injections of trapidil

細(xì)胞實(shí)驗(yàn)：

Cell viability was determined by Trypan blue dye exclusion test and LDH assay. Supernatants, collected from cells seeded in serum-free medium and exposed to the different mitogens and drugs tested, were centrifuged and LDH concentration determined. Supernatants obtained from sonicated cells were used as a positive control. Furthermore, to definitely exclude a cytotoxic effect of Trapidil on human MC, cells incubated for four days with and without the drug were challenged with fresh medium containing 10% FBS, and cell proliferation evaluated. (Only for Reference)

參考文獻(xiàn)：

1.Gesualdo L, et al. Kidney Int. 1994, 46(4):1002-9. 2.Kim SD, et al. Biochem Pharmacol. 2013, 86(6):782-90. 3.Maresta A, et al. Circulation. 1994, 90(6):2710-5.

溶解性：

Ethanol:39 mg/mL (190 mM) DMSO:39 mg/mL (190 mM) H2O:38 mg/mL (185.1 mM)

保存條件：

-20℃,避光

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.872 ml	24.359 ml	48.719 ml
5 mM	0.974 ml	4.872 ml	9.744 ml
10 mM	0.487 ml	2.436 ml	4.872 ml
50 mM	0.097 ml	0.487 ml	0.974 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(1篇)

1. [IF=4.8] Zihao Wang et al."Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis."Frontiers in Pharmacology.2025 Jun;16:

質(zhì)檢證書(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(COA)?

請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
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摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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