貨號	規格	價格	上海	北京	武漢	南京
S80398-2mg	99.9%	￥216.00 S80398-2mg ￥216.00 現貨	5 5	-	-	-
S80398-5mg	99.9%	￥304.00 S80398-5mg ￥304.00 現貨	6 6	-	-	-
S80398-10mg	99.9%	￥432.00 S80398-10mg ￥432.00 現貨	5 5	-	-	-
S80398-25mg	99.9%	￥800.00 S80398-25mg ￥800.00 現貨	6 6	-	-	-
S80398-50mg	99.9%	￥1200.00 S80398-50mg ￥1200.00 現貨	6 6	-	-	-
S80398-100mg	99.9%	￥2240.00 S80398-100mg ￥2240.00 現貨	2 2	-	-	-
S80398-200mg	≥99%	￥3200.00 S80398-200mg ￥3200.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產品

加入購物車

產品介紹

AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

產品描述：

AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

靶點：

EGFR:3 nM (IC50);HCV;EMCV ;EGFR;HCVProtease;InfluenzaVirus;HER;PDGFR

體內研究：

Administration of AG-1478 (AG1478) significantly reduces myocardial inflammation, fibrosis, apoptosis, and dysfunction in both two obese mouse models. ApoE-/- mice are first fed with HFD for 8 weeks (ApoE-HFD), and then administrated with AG-1478 (10 mg/kg/day) or 542 (10 mg/kg/day) for another 8 weeks by oral gavage. AG-1478 or 542 treatment blocks HFD induced cardiac EGFR phosphorylation in vivo, without affecting the plasma level of low density lipoprotein (LDL) and total triglyceride (TG). Administration of EGF (10 nM) leads to a robust and reproducible elevation in EGFR phosphorylation that can be blocked by AG-1478 (AG1478), a known inhibitor of EGFR phosphorylation. Increasing doses of Polyfect (PF) result in a significant reduction in EGF-induced EGFR phosphorylation (p<0.05) but this is to a lesser extent than observed with AG1478

參考文獻：

1. Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95. 2. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. 3. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. 4. Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6.

溶解性：

DMSO : 50 mg/mL (158.35 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.839 ml	14.196 ml	28.393 ml
5 mM	0.568 ml	2.839 ml	5.679 ml
10 mM	0.284 ml	1.42 ml	2.839 ml
50 mM	0.057 ml	0.284 ml	0.568 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

AG-1478 (Tyrphostin AG-1478)

4-(3-Chloroanilino)-6,7-Dimethoxyquinazoline Hydrochloride