貨號	規格	價格	上海	北京	武漢	南京
S80360-1mg	99.3%	￥150.00 S80360-1mg ￥150.00 現貨	10 10	-	-	-
S80360-5mg	99.3%	￥280.00 S80360-5mg ￥280.00 現貨	9 9	-	-	-
S80360-10mg	99.3%	￥807.00 S80360-10mg ￥807.00 現貨	7 7	-	-	-
S80360-25mg	99.3%	￥960.00 S80360-25mg ￥960.00 現貨	7 7	-	-	-
S80360-100mg	99.3%	￥3050.00 S80360-100mg ￥3050.00 現貨	7 7	-	-	-

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產品介紹

Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.

產品描述：

靶點：

ASK1:8.3 (pIC50);Apoptosis;ASK;MAPK

體外研究：

Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain

參考文獻：

1. Lanier M, et al. Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320. 2. Lin JH, et al. Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33. 3. Loomba R, et al. The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2trial. Hepatology. 2018 Feb;67(2):549-559.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.245 ml	11.224 ml	22.447 ml
5 mM	0.449 ml	2.245 ml	4.489 ml
10 mM	0.224 ml	1.122 ml	2.245 ml
50 mM	0.045 ml	0.224 ml	0.449 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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