貨號	規(guī)格	價格	上海	北京	武漢	南京
S80359-1mg	99.8%	￥360.40 S80359-1mg ￥360.40 現(xiàn)貨	2005 >10	-	-	-
S80359-5mg	99.8%	￥530.00 S80359-5mg ￥530.00 現(xiàn)貨	407 >10	-	-	-
S80359-10mg	99.8%	￥600.00 S80359-10mg ￥600.00 現(xiàn)貨	208 >10	-	-	-
S80359-25mg	99.8%	￥1140.00 S80359-25mg ￥1140.00 現(xiàn)貨	86 >10	-	-	-
S80359-50mg	99.8%	￥2200.00 S80359-50mg ￥2200.00 現(xiàn)貨	45 >10	-	-	-
S80359-100mg	99.8%	￥3800.00 S80359-100mg ￥3800.00 現(xiàn)貨	25 >10	-	-	-

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產(chǎn)品介紹

Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity

產(chǎn)品描述：

靶點：

12 nM (mouse IDH1R132H);Dehydrogenase;IsocitrateDehydrogenase(IDH)

體外研究：

Ivosidenib (AG-120) (0-13 μM; 48 hours) inhibits several IDH1-R132 mutants with potency similar IC50 values: IDH1-R132H (IC50=12 nM); IDH1-R132C (IC50=13 nM); IDH1-R132G (IC50=8 nM); IDH1-R132L (IC50=13 nM); IDH1-R132S (IC50=12 nM), respectively

體內(nèi)研究：

AG-120 (gavage administration; 50 mg/kg and 150 mg/kg) declines tumor 2-HG concentration rapidly, with maximum inhibition (92.0% and 95.2% at the 50 mg/kg and 150 mg/kg doses, respectively) achieved at -12 h post dose. Animal Model: Female nude BALB/c mice inoculated with HT1080 cells Dosage: 50 mg/kg and 150 mg/kg Administration: Gavage administration; 50 mg/kg and 150 mg/kg Result: Showed robust tumor 2-HG reduction in mouse.

參考文獻：

1. Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1Mutant Cancers. ACS Med Chem Lett. 2018 Jan 19;9(4):300-305.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.715 ml	8.577 ml	17.154 ml
5 mM	0.343 ml	1.715 ml	3.431 ml
10 mM	0.172 ml	0.858 ml	1.715 ml
50 mM	0.034 ml	0.172 ml	0.343 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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