品牌	貨號	產品規格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S80346-5mg	≥98%(HPLC)	￥440.00元	>10	-	-	-
源葉(MedMol)	S80346-10mg	≥98%(HPLC)	￥700.00元	>10	-	-	-
源葉(MedMol)	S80346-25mg	≥98%(HPLC)	￥1400.00元	>10	-	-	-
源葉(MedMol)	S80346-50mg	≥98%(HPLC)	￥2300.00元	10	-	-	-
源葉(MedMol)	S80346-100mg	≥98%(HPLC)	￥3700.00元	5	-	-	-
源葉(MedMol)	S80346-200mg	≥98%(HPLC)	￥6000.00元	2	-	-	-

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產品介紹

IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC50 of 0.5 nM.

產品描述： IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC50 of 0.5 nM.

靶點： EC50 Value: 0.5 nM;Porcupine

體外研究：
IWP-L6 (Porcn Inhibitor III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys .

體內研究：
IWP-L6 (Porcn Inhibitor III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity

參考文獻：
1. Wang, X., et al., The development of highly potent inhibitors for porcupine. J Med Chem, 2013. 56(6): p. 2700-4.

溶解性： Soluble in DMSO

保存條件： -20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.116 ml	10.58 ml	21.16 ml
5 mM	0.423 ml	2.116 ml	4.232 ml
10 mM	0.212 ml	1.058 ml	2.116 ml
50 mM	0.042 ml	0.212 ml	0.423 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

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IWP L6 ≥98%(HPLC)

IWP L6