| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S80338-2mg |
99.7% | ￥204.00 | 4 | - | - | - |
|
S80338-5mg |
99.7% | ￥306.00 | 8 | - | - | - |
|
S80338-10mg |
99.7% | ￥578.00 | 9 | - | - | - |
|
S80338-25mg |
99.7% | ￥952.00 | 8 | - | - | - |
|
S80338-50mg |
99.7% | ￥1768.00 | 3 | - | - | - |
|
S80338-100mg |
≥99% | ￥3060.00 | 貨期：2-3天 | - | - | - |
|
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM.
| 產品描述： | NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | IC50: 30 nM;p97 | ||||||||||||||||||||
| 體外研究： | NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value | ||||||||||||||||||||
| 參考文獻： | 1. Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
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危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京