貨號	規格	價格	上海	北京	武漢	南京
S80274-2mg	96.0%	￥255.00 S80274-2mg ￥255.00 現貨	5 5	-	-	-
S80274-5mg	96.0%	￥357.00 S80274-5mg ￥357.00 現貨	5 5	-	-	-
S80274-10mg	96.0%	￥552.00 S80274-10mg ￥552.00 現貨	5 5	-	-	-
S80274-25mg	96.0%	￥1105.00 S80274-25mg ￥1105.00 現貨	6 6	-	-	-
S80274-50mg	≥96%	￥1890.00 S80274-50mg ￥1890.00 2-3天	0 貨期：2-3天	-	-	-
S80274-100mg	≥96%	￥3060.00 S80274-100mg ￥3060.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.

產品描述：

Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.

靶點：

CDK1/Cyc B1:30 nM (IC50);CDK2/Cyc E:170 nM (IC50);CDK4/Cyc D1:100 nM (IC50);MAP:19000 nM (IC50);PKC:14000 nM (IC50);EGFR:22000 nM (IC50);HIVProtease;CDK;Autophagy

參考文獻：

1. Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273. 2. Keskin H, et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11. 3. Kim KS, et al.Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34.

溶解性：

DMSO : ≥ 20 mg/mL (45.63 mM) H2O : ≥ 20 mg/mL (45.63 mM) DMF : 7.69 mg/mL (17.55 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.282 ml	11.408 ml	22.815 ml
5 mM	0.456 ml	2.282 ml	4.563 ml
10 mM	0.228 ml	1.141 ml	2.282 ml
50 mM	0.046 ml	0.228 ml	0.456 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Flavopiridol HCl

Flavopiridol Hydrochloride