貨號	規格	價格	上海	北京	武漢	南京
S80231-50mg	99.9%	￥680.00 S80231-50mg ￥680.00 現貨	8 8	-	-	-
S80231-100mg	99.9%	￥1020.00 S80231-100mg ￥1020.00 現貨	4 4	-	-	-
S80231-500mg	≥99%	￥3740.00 S80231-500mg ￥3740.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

產品描述：

靶點：

D3 Receptor:0.71 nM (Ki);D2 Receptor:4-15 nM (Ki);D5 Receptor:4-15 nM (Ki);D4 Receptor:4-15 nM (Ki);D1 Receptor:83 nM (Ki);α1A:176 nM (Ki);α1B:273 nM (Ki);α2A:338 nM (Ki);α2B:27 nM (Ki);5-HT1A Receptor:30 nM (Ki);5-HT7 Receptor:86 nM (Ki);DopamineReceptor;5-HTReceptor;AdrenergicReceptor

體內研究：

In primed rats, Rotigotine (N-0923) (0.035, 0.1 and 0.35 mg/kg) induces contralateral turning behavior in a dose dependent manner. In drug naive rats, the turning behavior induced by Rotigotine, either alone or in combination with SCH 39166, is reduced compared to primed rats

參考文獻：

1. Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35. 2. Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86. 3. Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91. 4. Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP? and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.

溶解性：

DMSO : ≥ 50 mg/mL (142.07 mM) H2O : 4.76 mg/mL (13.53 mM; ultrasonic and warming and heat to 60°C)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.841 ml	14.207 ml	28.414 ml
5 mM	0.568 ml	2.841 ml	5.683 ml
10 mM	0.284 ml	1.421 ml	2.841 ml
50 mM	0.057 ml	0.284 ml	0.568 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Rotigotine Hydrochloride ( N-0923 Hydrochloride)

(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride