貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80214-5mg	≥98%	￥555.00 S80214-5mg ￥555.00 現(xiàn)貨	10 10	-	-	-
S80214-25mg	≥98%	￥2060.00 S80214-25mg ￥2060.00 現(xiàn)貨	10 10	-	-	-
S80214-100mg	≥98%	￥5150.00 S80214-100mg ￥5150.00 現(xiàn)貨	2 2	-	-	-

產(chǎn)品介紹

AZD3514 is an orally activie and selective androgen receptor (AR) inhibitor. AZD3514 androgen-dependently and -independently inhibits AR signal. AZD351 down-regulates nuclear AR levels in human LNCaP prostate cancer cells in the absence of androgen with an pIC50 value of 5.75. AZD3514 can be used for the research of prostate cancer

產(chǎn)品描述：

靶點(diǎn)：

Androgen Receptor;AndrogenReceptor

體內(nèi)研究：

AZD3514 (10-100 mg/kg; p.o. once daily for 6 days) inhibits AR signaling in rats. AZD3514 (50 mg/kg; p.o. once daily for 30 days) inhibits prostate tumor growth. AZD3514 (50-100 mg/kg; p.o. once daily for 3 days) significantly reduces nuclear AR protein in vivo

參考文獻(xiàn)：

1. Bradbury RH, et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8. 2. Loddick SA, et al. AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther. 2013 Sep;12(9):1715-27. 3. Omlin A, et al. AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer - results of two parallel first-in-human phase I studies. Invest New Drugs. 2015 Jun;33(3):679-90.

溶解性：

Soluble in DMSO

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.925 ml	9.624 ml	19.247 ml
5 mM	0.385 ml	1.925 ml	3.849 ml
10 mM	0.192 ml	0.962 ml	1.925 ml
50 mM	0.038 ml	0.192 ml	0.385 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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AZD3514