貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80186-2mg	99.3%	￥306.00 S80186-2mg ￥306.00 現(xiàn)貨	2 2	-	-	-
S80186-5mg	99.3%	￥425.00 S80186-5mg ￥425.00 現(xiàn)貨	3 3	-	-	-
S80186-10mg	99.3%	￥595.00 S80186-10mg ￥595.00 現(xiàn)貨	2 2	-	-	-
S80186-25mg	99.3%	￥1360.00 S80186-25mg ￥1360.00 現(xiàn)貨	4 4	-	-	-
S80186-50mg	99.3%	￥2380.00 S80186-50mg ￥2380.00 現(xiàn)貨	5 5	-	-	-
S80186-100mg	≥99%	￥3800.00 S80186-100mg ￥3800.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.

產(chǎn)品描述：

Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.

靶點(diǎn)：

mTORC1:2-10 nM (IC50);mTORC2:2-10 nM (IC50);mTOR:3 nM (IC50);DNA-PK:1 μM (IC50);PI3K-α:1.8 μM (IC50);ATM:0.6 μM (IC50);hVps34:3 μM (IC50);Autophagy;DNA-PK;PI3K;mTOR;Autophagy

體內(nèi)研究：

Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues

參考文獻(xiàn)：

1. Thoreen CC, et al, An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem, 2009, 284(12), 8023-8032. 2. Liu Q, et al. Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Che 3. Bi C, et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764. 4. Brandt M, et al. mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. Cell Metab. 2018 Jan 9;27(1):118-135.e8.

溶解性：

DMSO : 2 mg/mL (3.29 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.646 ml	8.229 ml	16.458 ml
5 mM	0.329 ml	1.646 ml	3.292 ml
10 mM	0.165 ml	0.823 ml	1.646 ml
50 mM	0.033 ml	0.165 ml	0.329 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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