貨號	規格	價格	上海	北京	武漢	南京
S80184-5mg	99.2%	￥150.00 S80184-5mg ￥150.00 現貨	5 5	-	-	-
S80184-10mg	99.2%	￥270.00 S80184-10mg ￥270.00 現貨	7 7	-	-	-
S80184-25mg	99.2%	￥535.00 S80184-25mg ￥535.00 現貨	6 6	-	-	-
S80184-50mg	99.2%	￥870.00 S80184-50mg ￥870.00 現貨	5 5	-	-	-
S80184-100mg	99.2%	￥1436.50 S80184-100mg ￥1436.50 現貨	5 5	-	-	-
S80184-200mg	≥98%	￥2150.00 S80184-200mg ￥2150.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons.

產品描述：

CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons.

靶點：

PI3Kγ:30 nM (IC50, Neurons);Apoptosis;PI3K

體內研究：

Administration of CAY10505 (0.6 mg/kg, p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly increases serum nitrite and (or) nitrate concentrations in hypertensive rats. Acetylcholine (ACh) and Sodium nitroprusside (SNP) produce endothelium-dependent and-independent relaxation in isolated rat aortic ring precontracted with Phenylephrine (3 μM), in a dose dependent manner. Administration of CAY10505 (0.6 mg/kg,p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly prevents hypertension-induced attenuation of ACh-induced endothelium-dependent relaxation. Deoxycorticosterone acetate salt (DOCA, 40 mg/kg, s.c.) induced hypertension markedly attenuates acetylcholine-induced endothelium-dependent relaxation, but does not affect SNP-induced endotheliumindependent relaxation

參考文獻：

1. Sun YY, Lin SH et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. 2013 Jul 19;8(7):e69019. 2. Tyagi S. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul, 90(7), 881-5. 3. Hofmann C, et al. PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform. Br J Haematol. 2014 Aug;166(4):529-39. 4. Jingyi Wang, et al. MiR-1976 Knockdown Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties Inducing Triple-Negative Breast Cancer Metastasis. Cell Death Dis. 2020 Jul 3;11(7):500.

溶解性：

DMSO : ≥ 34 mg/mL (117.53 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.457 ml	17.284 ml	34.569 ml
5 mM	0.691 ml	3.457 ml	6.914 ml
10 mM	0.346 ml	1.728 ml	3.457 ml
50 mM	0.069 ml	0.346 ml	0.691 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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