貨號	規格	價格	上海	北京	武漢	南京
S80166-5mg	99.0%	￥400.00 S80166-5mg ￥400.00 現貨	4 4	-	-	-
S80166-10mg	99.0%	￥700.00 S80166-10mg ￥700.00 現貨	7 7	-	-	-
S80166-25mg	99.0%	￥1200.00 S80166-25mg ￥1200.00 現貨	2 2	-	-	-
S80166-50mg	≥99%	￥1600.00 S80166-50mg ￥1600.00 2-3天	0 貨期：2-3天	-	-	-
S80166-100mg	≥99%	￥2100.00 S80166-100mg ￥2100.00 2-3天	0 貨期：2-3天	-	-	-
S80166-200mg	≥99%	￥4000.00 S80166-200mg ￥4000.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.

產品描述：

DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.

靶點：

IC50: 27 nM (ALK1), 107.9 nM (ALK2), <5 nM (ALK3), 47.6 nM (ALK6);ALK;Autophagy;TGF-beta/Smad

體內研究：

DMH1 (5 mg/kg, i.p.) treatment significantly reduces the tumor growth in human lung cancer xenograft model

參考文獻：

1. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of mL347 as an ALK2 versus ALK 2. Sheng Y, et al. DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy. Acta Pharm Sin B. 2015 Jul;5(4):330-6. 3. Neely MD, et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci. 2012 Jun 20;3(6):482-91. 4. Hover LD, et al. Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. Cancer Lett. 2015 Nov 1;368(1):79-87. 5. Hao J, et al. DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer. PLoS One. 2014 Mar 6;9(6):e90748.

溶解性：

DMSO : 11.5 mg/mL (30.23 mM; Need ultrasonic and warming)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.629 ml	13.143 ml	26.285 ml
5 mM	0.526 ml	2.629 ml	5.257 ml
10 mM	0.263 ml	1.314 ml	2.629 ml
50 mM	0.053 ml	0.263 ml	0.526 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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DMH 1