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產品描述： Sal003 is a potent, specific and cell-permeable inhibitor of the eukaryotic translation initiation factor 2α (eIF2α) phosphatase. Sal003 is a derivative of salubrinal |
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靶點：
eIF2α phosphatase;Apoptosis |
體內研究：
Sal003 (20Μm; intrahippocampal injection; 8 minutes) impairs contextual memory in vivo |
參考文獻：
1. Costa-Mattioli M, et al. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 2007 Apr 6;129(1):195-206. 2. Yahiro K, et al. Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells. Infect Immun. 2012 May;80(5):1803-14. |
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溶解性：
DMSO : ≥ 100 mg/mL (215.88 mM) |
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保存條件：
2-8℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
2.163 ml |
10.817 ml |
21.635 ml |
| 5 mM |
0.433 ml |
2.163 ml |
4.327 ml |
| 10 mM |
0.216 ml |
1.082 ml |
2.163 ml |
| 50 mM |
0.043 ml |
0.216 ml |
0.433 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
北京