貨號	規格	價格	上海	北京	武漢	南京
S80071-1mg	98.3%	￥100.00 S80071-1mg ￥100.00 現貨	6 6	-	-	-
S80071-5mg	98.3%	￥130.00 S80071-5mg ￥130.00 現貨	11 >10	-	-	-
S80071-25mg	98.3%	￥490.00 S80071-25mg ￥490.00 現貨	12 >10	-	-	-
S80071-100mg	98.3%	￥1200.00 S80071-100mg ￥1200.00 現貨	6 6	-	-	-

產品介紹

Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM).

產品描述：

靶點：

IC50: 3.4 nM (20S proteasome) Ki: 0.93 nM (20S proteasome);Proteasome;Caspase;Autophagy

體內研究：

Ixazomib (MLN2238) shows antitumor activity in the CWR22 xenograft model. The antitumor effects of Ixazomib (MLN2238) dosed at 14 mg/kg i.v. or 7 mg/kg i.v. are compared with Bortezomib dosed at 0.8 mg/kg i.v. or 0.4 mg/kg i.v. on a twice weekly regimen. The high dose for both Ixazomib (MLN2238) and Bortezomib shows similar antitumor activity in this model (T/C=0.36 and 0.44, respectively). However, Ixazomib (MLN2238) (7 mg/kg) shows greater efficacy at a 0.5 MTD dose compared with a 0.5 MTD dose of Bortezomib (0.4 mg/kg; T/C=0.49 compared with T/C=0.79, respectively) Ixazomib (MLN2238) shows time-dependent reversible proteasome inhibition; however, the proteasome dissociation half-life (t1/2) for Ixazomib (MLN2238) is determined to be 18 minutes

參考文獻：

1. Kupperman E, et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010 Mar 1;70(5):1970-80.

溶解性：

DMSO : 62.5 mg/mL (173.12 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.77 ml	13.849 ml	27.699 ml
5 mM	0.554 ml	2.77 ml	5.54 ml
10 mM	0.277 ml	1.385 ml	2.77 ml
50 mM	0.055 ml	0.277 ml	0.554 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=13.2] Lingjun Ye et al."Thrombin-based multifunctional hemostat with robust adhesion and coagulation capacities for efficient hemostasis under high-temperature and high-humidity."CHEMICAL ENGINEERING JOURNAL.2025 Sep;519:164944

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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