品牌	貨號	產品規格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S80057-10mg	98%	￥160.00元	>10	-	-	-
源葉(MedMol)	S80057-50mg	98%	￥288.00元	6	-	-	-
源葉(MedMol)	S80057-100mg	98%	￥560.00元	6	-	-	-
源葉(MedMol)	S80057-200mg	98%	￥1040.00元	預計交期：2-3天	-	-	-

產品介紹

Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.

產品描述： Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.

靶點： VEGFRInfluenza Virus;PDGFR;EGFR;VEGFR;InfluenzaVirus;PDGFR

參考文獻：
1. Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408(3):465-70. 2. Richard F. Loeser, Christopher B. Forsyth, Allen M. Samarel et al. Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2 Mediates Integrin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependen 3. Michele Fuortes, Maxine Melchior, Hyunsil Han, et al. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest. 1999;104(3):327-335. 4. Johan Thyberg . Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. European Journal of Cell Biology.1998,76(1): 33-42 5. R Marhaba, F Mary, C Pelassy, et al. Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. The Journal of Immunology. 1996,157 (4): 1468-1473 6. Kumar N, et al. Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. J Virol. 2011 Mar;85(6):2818-2

溶解性： DMSO : 50 mg/mL (177.07 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.541 ml	17.707 ml	35.413 ml
5 mM	0.708 ml	3.541 ml	7.083 ml
10 mM	0.354 ml	1.771 ml	3.541 ml
50 mM	0.071 ml	0.354 ml	0.708 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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