品牌	貨號	產品規格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S23408-1mg	98%	￥80.00元	10	-	-	-
源葉(MedMol)	S23408-5mg	98%	￥110.00元	7	-	-	-
源葉(MedMol)	S23408-10mg	98%	￥200.00元	7	-	-	-
源葉(MedMol)	S23408-25mg	98%	￥400.00元	7	-	-	-
源葉(MedMol)	S23408-100mg	98%	￥1060.00元	7	-	-	-

產品介紹

MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake

產品描述：

靶點：

IGF-1R

體外研究：

MID-1 (5 μM; 24 h) increases the IRS-1 expression level in skeletal muscle by disrupting the MG53-IRS-1 interaction.

MID-1 (10 μM; 12 h) reduces the luciferase activity in HEK 293 cell line expressing NLUC-IRS-1 and CLUC-C14A.

MID-1 (1-20 μM; 12 h) disrupts the MG53-IRS-1 interaction but not MG53-FAK interaction in HEK 293 cells.

MID-1 (0.1-10 μM; 4-24 h) abolishes MG53-induced IRS-1 ubiquitination and degradation in HEK 293 cells.

MID-1 (5-10 μM; 24 h) increases insulin signaling and insulin-elicited glucose uptake in C2C12 myotubes.

MID-1 (5-10 μM; 24 h) enhances skeletal myogenesis.

體內研究：

MID-1 does not have good pharmacokinetics in vivo.

參考文獻：

1. Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.409 ml	17.047 ml	34.095 ml
5 mM	0.682 ml	3.409 ml	6.819 ml
10 mM	0.341 ml	1.705 ml	3.409 ml
50 mM	0.068 ml	0.341 ml	0.682 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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