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MAP4K4-IN-3 98%

源葉(MedMol)
S23234
1811510-58-3
C15H12ClN5
297.74
品牌 貨號 產品規格 價格(RMB) 庫存(上海) 北京 武漢 南京 購買數量
源葉(MedMol) S23234-5mg 98% ¥297.50元 9 - - -
源葉(MedMol) S23234-10mg 98% ¥552.50元 8 - - -
源葉(MedMol) S23234-25mg 98% ¥1232.50元 7 - - -
源葉(MedMol) S23234-100mg 98% ¥2900.00元 2 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent
產品描述: MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent
靶點: MAP4K4:14.9 nM (IC50);MAPK
體內研究: Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3
參考文獻: 1. Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. 2. Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61(7):3114-3125.
溶解性: DMSO  :  10  mg/mL  (33.59  mM;  ultrasonic  and  warming  and  heat  to  60°C)
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 3.359 ml 16.793 ml 33.586 ml
5 mM 0.672 ml 3.359 ml 6.717 ml
10 mM 0.336 ml 1.679 ml 3.359 ml
50 mM 0.067 ml 0.336 ml 0.672 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

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批號:JS298415 貨號:S20001-25g
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摩爾濃度計算器

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