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別嘌醇

    
分析標(biāo)準(zhǔn)品,HPLC≥98%

Allopurinol

源葉
B27249 一鍵復(fù)制產(chǎn)品信息
315-30-0
C5H4N4O
136.11
MFCD00599413
別嘌呤醇;1H-吡唑并[3,4-d]嘧啶-4-醇;4-羥基吡唑并[3,4-d]嘧啶;HPP
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
B27249-20mg
分析標(biāo)準(zhǔn)品,HPLC≥98% ¥300.00 >10 - 4 2
B27249-100mg
分析標(biāo)準(zhǔn)品,HPLC≥98% ¥1050.00 >10 - - -
B27249-1g
分析標(biāo)準(zhǔn)品,HPLC≥98% ¥4500.00 >10 - - -
產(chǎn)品介紹 參考文獻(36篇) 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Allopurinol 是一種有效的口服活性黃嘌呤氧化酶 xanthine oxidase 抑制劑,IC50值為0.2-50 µM。Allopurinol 可用于治療高尿酸血癥和痛風(fēng)。Allopurinol 降低 HIF-1α 和 HIF-2α 蛋白的表達。Allopurinol 顯示出抗抑郁和抗傷害活性。Allopurinol 具有抗利什曼原蟲作用。

熔點: 384°C
沸點: 290.8°C at 760 mmHg
外觀: 白色至灰白色固體
溶解性: DMSO  :  14  mg/mL  (102.86  mM;  Need  ultrasonic  and  warming)
H2O  :  1  mg/mL  (7.35  mM;  ultrasonic  and  adjust  pH  to  11  with  NaOH)
敏感性: 對光敏感
儲存條件: 2-8℃
注意: 部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。

參考文獻(36篇)

31. [IF=5.2] Haiying Wang et al."Screening and evaluation of a novel nucleotide-degrading Levilactobacillus brevis grx821 with anti-hyperuricemia ability."Food Bioscience".2024 Aug;60:104337 30. [IF=5.2] Jun Li et al."Xanthine oxidase inhibitory activity of quercetin and its derivatives: Interaction mechanism and evaluation methods."Food Bioscience".2024 Jun;59:103982 29. [IF=7.3] Zhang Qing-zheng et al."Fangyukangsuan granules ameliorate hyperuricemia and modulate gut microbiota in rats."Frontiers in Immunology".2024 Apr;15: 28. [IF=3.4] Wen-Wen Liu et al."Analyzing chemical composition of Sargentodoxae caulis water extract and their hypouricemia effect in hyperuricemic mice."FITOTERAPIA".2024 Mar;:105926 27. [IF=3.4] Huanying Guo et al."Screening and characterization of potential anti-gout components from Polygonum cuspidatum by integration off-line two-dimensional liquid chromatography-mass spectrometry with affinity ultrafiltration and on-line HPLC-ABTS."JOURNAL OF 26. [IF=4.3] Guitao Xu et al."Eupatilin inhibits xanthine oxidase in vitro and attenuates hyperuricemia and renal injury in vivo."FOOD AND CHEMICAL TOXICOLOGY.2024 Jan;183:114307 25. [IF=5.2] Zhipeng Zheng et al."Polyphenol Composition, Antioxidant Capacity and Xanthine Oxidase Inhibition Mechanism of Furong Plum Fruits at Different Maturity Stages."Foods.2023 Jan;12(23):4253 24. [IF=5.2] Weimin Hu et al."Identification of anti-hyperuricemic components from Cichorium intybus L. taproots."Food Bioscience.10.1016/j.fbio.2023.103145 23. [IF=5] Liu Yue et al."Characterizations of microRNAs involved in the molecular mechanisms underlying the therapeutic effects of noni (Morinda citrifolia L.) fruit juice on hyperuricemia in mice."Frontiers in Nutrition.2023 Jun;10: 22. [IF=5.2] Biqian Wei et al."Guluronate oligosaccharides exerts beneficial effects on hyperuricemia and regulation of gut microbiota in mice."Food Bioscience.2023 Jun;:102855 21. [IF=4.927] Jing Chen et al."Screening of Tyrosinase, Xanthine Oxidase, and α-Glucosidase Inhibitors from Polygoni Cuspidati Rhizoma et Radix by Ultrafiltration and HPLC Analysis."MOLECULES.2023 Jan;28(10):4170 20. [IF=2.358] Ziyuan Liu et al."Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signaling pathway."NEPHROLOGY.2023 Mar;: 19. [IF=2.65] Lifei Fan et al."Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments."Evidence-based Complementary and Alternative Medicine.2023;2023:6931644 18. [IF=4.036] Pei He et al."Unveiling the inhibitory mechanism of aureusidin targeting xanthine oxidase by multi-spectroscopic methods and molecular simulations."RSC Advances.2023 Jan;13(3):1606-1616 17. [IF=6.706] Biqian Wei et al."Ameliorative Effect of Mannuronate Oligosaccharides on Hyperuricemic Mice via Promoting Uric Acid Excretion and Modulating Gut Microbiota."Nutrients.2023 Jan;15(2):417 16. [IF=6.59] Yaolei Li et al."Bioactive-Chemical Quality Markers Revealed: An Integrated Strategy for Quality Control of Chicory."Frontiers in Nutrition.2022; 9: 934176 15. [IF=6.706] Dan Wu et al."Tea (Camellia sinensis) Ameliorates Hyperuricemia via Uric Acid Metabolic Pathways and Gut Microbiota."Nutrients.2022 Jan;14(13):2666 14. [IF=4.24] Jun Li et al."In vitro xanthine oxidase inhibitory properties of Flos Sophorae Immaturus and potential mechanisms."Food Biosci. 2022 Jun;47:101711 13. [IF=3.373] Yiyuan Luo et al."Quality evaluation of Tetrastigma hemsleyanum different parts based on quantitative analysis of 42 bioactive constituents combined with multivariate statistical analysis."PHYTOCHEMICAL ANALYSIS. 2022 Apr 05 12. [IF=3.24] Yinfang Gao et al."Uricase-deficient rats with similarly stable serum uric acid to human’s are sensitive model animals for studying hyperuricemia."Plos One. 2022 Mar;17(3):e0264696 11. [IF=3.591] Yongjie Liu et al."Inhibition and molecular mechanism of diosmetin against xanthine oxidase by multiple spectroscopies and molecular docking."New J Chem. 2020 May;44(17):6799-6809 10. [IF=3.981] Wenhao Xu et al."Self-assembled nanocapsules of celery (Apium graveolens Linn) seed oil: Mechanochemical preparation, characterization and urate-lowering activity."J Drug Deliv Sci Tec. 2021 Dec;66:102810 9. [IF=4.219] Huilong Xiang et al."Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy."Toxicol Appl Pharm. 2021 Aug;424:115594 8. [IF=4.411] Xiaoke Wang et al."Novel Carbon Dots Derived from Puerariae lobatae Radix and Their Anti-Gout Effects."Molecules. 2019 Jan;24(22):4152 7. [IF=7.132] Li Yang et al."Supercritical extraction and antioxidant activity of major ingredients in Puerariae lobatae root, Pinus massoniana needle, Citrus reticulata peel and their mixture."J Co2 Util. 2021 Jun;48:101518 6. Liu, Yongjie, et al. "Inhibition and molecular mechanism of diosmetin against xanthine oxidase by multiple spectroscopies and molecular docking."?New Journal of Chemistry?44.17 (2020): 6799-6809.https://doi.org/10.1039/D0NJ00679C 5. 鐘英英,周佳明,葉美鳳,何湘惠,邢韓寒,葉云.辣木葉提取物對黃嘌呤氧化酶活性的抑制[J].食品工業(yè),2020,41(11):55-58. 4. 邢志華, 包然, 姜婧雯,等. 芹菜素-釤配合物的合成及其抗小鼠高尿酸血癥研究. 天然產(chǎn)物研究與開發(fā). 3. 張雅, 王一喬, 馬卓雅,等. 藥效學(xué)實驗結(jié)合正交試驗優(yōu)選壯藥柏金顆粒的水提醇沉工藝[J]. 中國藥房, 2020, v.31;No.674(08):28-34. 2. 李晶,劉雯,陳超,虞金寶.車前三個不同部位中主要化學(xué)成分含量差異及其黃嘌呤氧化酶體外抑制作用比較[J].實用中西醫(yī)結(jié)合臨床,2018,18(07):174-176. 1. 鄧寶琴, 鄒崢嶸. 無患子總皂苷的還原法脫色工藝研究[J]. 江西師范大學(xué)學(xué)報(自然科學(xué)版), 2019, 43(01):94-99.

質(zhì)檢證書(COA)

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摩爾濃度計算器

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