貨號	規格	價格	上海	北京	武漢	南京	購買數量
B25381-20mg	分析標準品,HPLC≥98%	￥160.00 B25381-20mg ￥160.00 2-3天	0 貨期：2-3天	-	-	-
B25381-100mg	分析標準品,HPLC≥98%	￥500.00 B25381-100mg ￥500.00 現貨	3 1 3	-	1	-

產品介紹

Oxaliplatin 是一種 DNA 合成抑制劑。Oxaliplatin 會導致 DNA 交聯損傷，阻止 DNA 復制和轉錄并導致細胞死亡。Oxaliplatin 以時間依賴方式抑制人黑色素瘤細胞系 C32 和 G361，IC50 值分別為 0.98 μM 和 0.14 μM。Oxaliplatin 可以誘導細胞自噬 (autophagy)。

沸點：	193.6 °C at 760 mmHg
比旋光度：	+74.5-78.0 (D/20)(c=0.5,H2O)
外觀：	白色疏松塊狀物或無定形固體
溶解性：	H2O : 2.17 mg/mL (5.46 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate Oxaliplatin's activity) DMF : 1.67 mg/mL (4.20 mM; Need ultrasonic; DMSO can inactivate Oxaliplatin's activity) Ethanol : < 1 mg/mL (insoluble; DMSO can inactivate Oxaliplatin's activity)
敏感性：	熱敏感
儲存條件：	2-8℃
注意：	部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(11篇)

11. [IF=4.6] Yanan Liu et al."QuEChERS and UPLC-MS/MS-Based Quantification of Human Plasma of Eight Nucleoside Reverse Transcriptase Inhibitors and Platinum Anticancer Drugs for Hepatocellular Carcinoma."MOLECULES.2025 Jan;30(10):2204 10. [IF=4.4] Qu Minmin et al."Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells."Frontiers in Pharmacology.2024 Jun;15: 9. [IF=5] Jiayue Xu et al."Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota."EUROPEAN JOURNAL OF PHARMACOLOGY".2024 May;971:176516 8. [IF=11.4] Anni Hu et al."A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer."Redox Biology.2023 Nov;:102959 7. [IF=9.9] Xingchen Li et al."Cancer cell membrane biomimetic nanosystem for homologous targeted dual-mode imaging and combined therapy."JOURNAL OF COLLOID AND INTERFACE SCIENCE.2023 Dec;652:770

6. [IF=5.1] Hongyan Lin et al."Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC."JOURNAL OF NATURAL PRODUCTS.2023;XXXX(XXX):XXX-XXX 5. [IF=1.703] Wang Man et al."Duloxetine alleviates oxaliplatin-induced peripheral neuropathy by regulating p53-mediated apoptosis."NEUROREPORT.2022 Jul;33(10):437-444 4. [IF=2.963] Zhiwen Yang et al."Ginsenoside Rh1 regulates gastric cancer cell biological behaviors and transplanted tumor growth in nude mice via the TGF-β/Smad pathway."CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY.2022 Jul;: 3. [IF=6.4] Yuxin Sun et al."In vitro and in vivo Evaluation of a Novel Estrogen-Targeted PEGylated Oxaliplatin Liposome for Gastric Cancer."Int J Nanomed. 2021 Dec;16:8279-8303 2. [IF=3.665] Jing Liang et al."Effects of long non-coding RNA Opa-interacting protein 5 antisense RNA 1 on colon cancer cell resistance to oxaliplatin and its regulation of microRNA-137."World J Gastroentero. 2020 Apr 7; 26(13): 1474–1489 1. [IF=6.843] Yuan-Fu Ding et al."Supramolecular nanomedicine derived from cucurbit[7]uril-conjugated nano-graphene oxide for multi-modality cancer therapy."Biomater Sci-Uk. 2021 May;9(10):3804-3813

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Oxaliplatin